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At our office in Wheat Ridge, we believe that the pursuit for optimal wellness is an active process of making choices toward a more healthy existence.
We strive for objectivity in nutritional healthcare as well as provide clear chiropractic and/or acupuncture options in our structural healthcare. We help Metro area residents reach optimum health, so they can reach their fullest potential in life.
Objective, Blood-Based Health Analysis
The most comprehensive nutrition and health program in the Denver Metro area. Based on a 52-point blood panel and an in-depth analysis of your urine and hair, your science based evaluation includes recommendations for supplements, foods to avoid, a comprehensive review of your current medications, side effects and more.
Personal Health Analysis
The science based nutrition evaluation and report represent the most comprehensive analysis available. Below are some of the key features that set us apart from others:
- Individualized supplement recommendations & dosages specific to test findings, age, sex, & weight of the patient
- Correlation of drug side effects with patient test finding
- Dietary recommendations with meal recipes
- Compare color-coded current and previous test results on the same page
- Incorporates multiple factors for each condition or diagnosis including the patients symptoms, medications, blood tests, hair tests, chelation and urine tests
I hope you'll choose our office for your nutritional health care need. We are prepared to graciously serve and help you achieve your individual health goals.
Dr. Holland | 303.422.7767
A Dr. Holland review of the current nutritional research
Changing Gene Expression – Powerful Anti-Aging Medicine
Exciting research from the University of Texas Health Science Center has identified what has now been termed the “master regulator of the aging process.” The process of aging seems to be quite directly correlated with the damaging affects upon our tissues of the actions of chemicals called free radicals. We are all familiar with the notion of taking antioxidants to quench free radicals and this has been a focus of scientific research for decades. And rightfully so. Free radicals are clearly involved in the damage that occurs to our fat, protein, and even our DNA. Ultimately, although our DNA, our code of life, has repair mechanisms, as we age, the ability of DNA to repair itself, finally fails.
Until quite recently, the main focus of antioxidant therapy has been to supply molecules that inactivate free radicals. That means, for example, that one molecule of vitamin C, could quench one free radical. But now leading edge research, like that mentioned above, is focusing on the vast amplification of the body’s own antioxidant systems whereby stimulating DNA can cause the body to actually manufacture vast numbers of protective antioxidant molecules, far more than anything you could take in a standard antioxidant supplement.
What these researchers and others are focused on is a chemical pathway called Nrf2. When the Nrf2 pathway is activated, it causes an explosive production of life preserving, anti-aging, protective antioxidants. The scientists in the research cited above revealed how the Nrf2 pathway is markedly activated in animals with enhanced lifespan. In fact, one of the key antioxidants amplified by this pathway is glutathione, now known as the the brain’s “master antioxidant.”
And beyond just enhancing antioxidant function, activation of the Nrf2 pathway turns off inflammation, while at the same time enhancing detoxification. The researchers indicated that Nrf2 regulates a diverse array of more than 200 cellular protective genes that neutralize and also detoxify both toxins formed within the body as well as those from environmental exposure.
This science is so profound that it has led to the development of a pharmaceutical agent now FDA approved for the treatment of multiple sclerosis, based on modulating the Nrf2 pathway. And beyond MS, Nrf2 is now looked upon as a “new therapeutic target in Parkinson’s disease.”
Other areas of research now include amyotrophic lateral sclerosis (Lou Gehrig’s disease), and Alzheimer’s disease as well.
But here’s some very good news. The Nrf2 pathway is readily activated by a variety of natural substances including the spice turmeric, green tea extract, pterostilbene (a form of resveratrol), glucoraphanin (found in broccoli), and even coffee. Many of these are readily available as nutritional supplements and can be far more effective at increasing antioxidant production than typical antioxidants.
Truly, we stand at the threshold of a new understanding of how we can change gene expression to enhance antioxidant function, reduce inflammation, and empower our bodies to detoxify. And how empowering it is to know that this can be accomplished nutritionally.
Vitamins K and D Important for Gut Health
A recent study found that vitamin K and vitamin D are low in subjects with imbalanced inflammatory responses in the intestines. Previous research indicated that proper balance of inflammation in the digestive tract is important for optimal bone mineral density. Thus, researchers investigated the role of vitamin D and vitamin K, both important vitamins for maintaining bone strength, in patients with unbalanced inflammatory responses in the bowel.
This study included 87 subjects with inflammatory imbalances of the intestines. The subjects were evaluated for bone mineral density using dual-energy X-ray absorptiometry (DEXA). In the subjects and healthy volunteers, levels of serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D were measured to determine vitamin K and vitamin D levels.
The results indicated that bone mineral density was suboptimal in the subjects with imbalanced inflammatory responses in the intestines. Additionally, the researchers found that vitamin D was lower in subjects with imbalanced inflammatory responses, and vitamin K also was lower in a subset of patients with imbalanced inflammatory responses compared to control subjects. The study also showed that serum undercarboxylated osteocalcin, the measurement of vitamin K in the body, correlated with clinical activity in a subset of the patients with inflammation affecting the large intestine.
The study authors concluded that vitamins D and K are insufficient in subjects with imbalanced inflammatory responses in the intestines, and vitamin K is associated with normal inflammatory processes in a subset of these patients.
Nakajima S, Iijima H, Egawa S, Shinzaki S, Kondo J, Inoue T, Hayashi Y, Ying J, Mukai A, Akasaka T, Nishida T, Kanto T, Tsujii M, Hayashi N. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011 Apr 8.
Folate Important for Breast Health
Recent research has reported that folic acid enhances breast health. Previous research has suggested that folate, vitamin B12, vitamin B6, niacin, riboflavin and methionine intake may play a role in breast health.
The subjects in the study were women enrolled in the Shanghai Women’s Health Study, including 718 women with breast health concerns. The women were evaluated for dietary intake of B vitamins, menopausal status, and the presence of risk factors associated with abnormal cell growth.
The results of the study showed that in premenopausal women, increased folate intake was associated with a decrease in the risk of suboptimal breast health. In fact, the women with the highest intake of folate had a 40 percent decrease in the risk of suboptimal breast health compared to the women with the lowest folate intake. The study did not find an association between B vitamins or methionine intake and suboptimal breast health in postmenopausal women.
The authors concluded that this study supports the hypothesis that high folate intake may support optimal breast health, and this association may depend on menopausal status and estrogen or progesterone receptor status.
Shrubsole MJ, Shu XO, Li HL, Cai H, Yang G, Gao YT, Gao J, Zheng W. Dietary B Vitamin and Methionine Intakes and Breast Cancer Risk Among Chinese Women. Am J Epidemiol. 2011 Mar 29.
St. John's Wort Studied for Memory and Cognitive Function
St. John’s wort (Hypericum perforatum) enhances stress-related suboptimal memory, as well as cognitive health in animals, according to a recently published study. Researchers suggest that St. John’s wort may modulate the synaptic plasticity proteins neuromodulin and synaptophysin, which are proteins important for the development of nerve cell axons and transmission of nerve signals.
Rats in this study were stressed, which induced a decline in the acquisition of spatial working memory demonstrated by poorer performance on maze tests. Some of the rats were supplemented with 350 mg/kg of St. John’s wort for 21 days. The rats were then reassessed for spatial memory using the maze test and evaluated for levels of neuromodulin and synaptophysin in the hippocampus and prefrontal cortex, which are areas of the brain involved in memory and executive functioning.
The study found that supplementation with St. John’s wort in the stressed rats resulted in significant improvements in processing of spatial information based on the maze tests. Additionally, St. John’s wort significantly increased levels of neuromodulin and synaptophysin in the hippocampus and prefrontal cortex of the rats.
The researchers stated, “These findings increase our understanding of the reaction of the hippocampus and prefrontal cortex to stressful assaults and provide new insight into the possible actions of H. perforatum in the treatment of patients with impaired adaptation to environmental stressors and simultaneously suffering from cognitive impairment.”
Trofimiuk E, Holownia A, Braszko JJ. St. John’s wort may relieve negative effects of stress on spatial working memory by changing synaptic plasticity. Naunyn Schmiedebergs Arch Pharmacol. 2011 Apr;383(4):415-22.
Vitamin D Supports Healthy Vision
A recent study revealed that higher levels of vitamin D may help with the maintenance of vision health as we age. The macula, which is an area on the retina in the back of the eye, can be affected by aging, resulting in loss of central vision.
The subjects in this study included 1,313 women enrolled in the Carotenoids in Age-Related Eye Disease Study. The women were evaluated with an eye exam for central vision loss and were assessed for serum 25-hydroxyvitamin D concentration. The women were also evaluated for potential confounding factors such as age, smoking, iris pigmentation, family history of central vision loss, heart health, blood sugar metabolism, and hormone use.
In the study, there were 241 women found to have early central vision loss. The results of the study found that increased serum concentrations of vitamin D were associated with healthy central vision in the women younger than 75 years of age. In fact, compared to the women with the lowest serum 25-hydroxyvitamin D concentrations, the women under age 75 with the highest vitamin D concentrations showed a 48 percent decrease in the risk of experiencing suboptimal central vision. Additionally, the researchers showed that in the women under age 75, intake of vitamin D from food and supplements was also related to central vision health.
The researchers concluded that high serum 25-hydroxyvitamin D concentrations may support central vision health in women younger than 75 years of age.
Millen AE, Voland R, Sondel SA, Parekh N, Horst RL, Wallace RB, Hageman GS, Chappell R, Blodi BA, Klein ML, Gehrs KM, Sarto GE, Mares JA; for the CAREDS Study Group. Vitamin D Status and Early Age-Related Macular Degeneration in Postmenopausal Women. Arch Ophthalmol. 2011 Apr;129(4):481-489.
Resveratrol Studied in Fat Tissue Deposition
Resveratrol, a polyphenol found in high concentration in the skins of red grapes, was recently shown to reduce adipose (fat) tissue deposition in rats. Previous research suggests that resveratrol has weight management benefits.
Rats in this study were fed a diet to induce significant weight gain for 6 weeks. One group of rats was also supplemented with resveratrol at a dose of 30 mg per kg body weight per day, while the other rats served as the control group. After 6 weeks, the rats were evaluated for amounts of white adipose tissue. Also, activity of several enzymes was measured, including lipoprotein lipase, which breaks down lipids, and enzymes involved in the synthesis of fatty acids (lipogenesis), including acetyl-CoA carboxylase, malic enzyme, glucose-6-phosphate-dehydrogenase, and fatty acid synthase. In addition, gene expression of several enzymes involved in lipid metabolism and resveratrol metabolite levels in the adipose tissue was also evaluated.
Body weight of the rats was not different between the two groups. However, the group of rats given resveratrol showed a significant decrease in adipose tissue. The researchers also showed that, in the resveratrol group, there was decreased activity in the enzymes involved with lipid synthesis and lipoprotein lipase, which breaks down triglycerides present in lipoproteins to free fatty acids. At the level of gene transcription, there was also a reduction of hormone-sensitive lipase mRNA levels, which is involved in the breakdown of the storage form of fats to free fatty acids.
The researchers stated, “It can be proposed that the body fat-lowering effect of resveratrol is mediated, at least in part, by a reduction in fatty acid uptake from circulating triacylglycerols and also in de novo lipogenesis.”
Alberdi G, Rodriguez VM, Miranda J, Macarulla MT, Arias N, Andres-Lacueva C, Portillo MP. Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond). 2011 May 10;(8):29.
Calcium Intake Insufficient in U.S. Adults
A recent report revealed that adults in the U.S. are not consuming adequate calcium for optimal health. Calcium is the most abundant mineral in the body. In addition to bone health, calcium is also important for vascular function, nerve transmission, muscle contraction and cell communication.
Data from the National Health and Nutrition Examination Survey from 2003-2006 was evaluated for calcium intake across adult age groups and calcium intake relative to total energy intake. Calcium intake and supplement use was assessed using 24-hour recall and questionnaires. Data was evaluated from 9,475 U.S. adults. The subjects were evaluated for dietary calcium, total calcium, energy intake, and calcium to energy intake ratios to measure nutrient density.
The results showed that in the age group including adults age 81 or older, the median dietary calcium intake was 23 percent lower in men and 14 percent lower in women compared to adults 19-30 years of age. Also, in the group of adults age 81 and older, the median energy intake was 35 percent lower in men and 28 percent lower in women. The study also found that calcium supplementation increased with age. In women who supplement calcium, the median dietary calcium intake declined greater than in the women who did not take calcium supplements. Furthermore, calcium density in the diet increased with age. However, the dietary calcium and total calcium to energy ratios were insufficient to meet target ratios for adequate intake standards in adults over age 50.
The study authors concluded, “Although supplemental calcium use and calcium density were highest in older age groups, they were not sufficient in meeting recommended levels.”
Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006. J Am Diet Assoc. 2011 May;111(5):687-95.
Maternal Iodine Studied for Psychomotor Development of Children
Maternal iodine levels were shown in a new study to correlate with development of the child during the first 2 years of life. Iodine is a trace mineral required for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid hormone is essential for normal metabolic activity and is critical for skeletal and central nervous system development in fetuses and infants.
In a moderately iodine deficient area, pregnant women were evaluated for serum free T4 levels during the first trimester of pregnancy. Eighty-six children from the women were evaluated for psychomotor development using the Bayley Scale of Infant Development at 12, 18 and 24 months of age.
The study showed that maternal serum free T4 levels were a major determinant of psychomotor development of the children at 18 and 24 months of age. In the children born to mothers with a serum T4 level in the lowest 25 percent, there was over double the risk of the children having mild-to-severe delay, and alterations in behavior were already found at 12 months of age. Thyroid status of the infant at birth did not influence psychomotor development.
The researchers stated, “This study highlights the need to implement active measures of iodine supplementation periconceptionally and during pregnancy and lactation because the negative effects on development and behavior might be prevented through preemptive action.”
Costeira MJ, Oliveira P, Santos NC, Ares S, Saenz-Rico B, Morreale de Escobar G, Palha JA. Psychomotor Development of Children from an Iodine-Deficient Region. J Pediatr. 2011 Apr 12.
Nerve Health Enhanced with Vitamins and Minerals
A new clinical trial suggests that a combination of vitamins and minerals can support nerve health in subjects with imbalanced blood sugar metabolism. Over time, nerve health can be affected in these individuals due to imbalanced blood sugar’s effects on the blood vessels that carry blood to the nerves. Imbalanced blood sugar also has a direct effect on nerves.
In this randomized, double-blind, placebo-controlled study, researchers assessed the impact of nutrient supplementation for 4 months in subjects with imbalanced blood sugar metabolism. One group of subjects received a combination of 20 mg of zinc, 250 mg of magnesium, 200 mg of vitamin C and 100 mg of vitamin E. The second group was supplemented with the same vitamins and minerals as group one, plus 10 mg of vitamin B1, 10 mg of vitamin B2, 10 mg of vitamin B6, 10 μg of vitamin B12, 1 mg of folic acid and 200 μg of biotin. The third group received a placebo supplement. Nerve health was assessed using a questionnaire.
The study found that nerve health was significantly enhanced in both supplement groups. The placebo group also saw a modest benefit over the four month period, but not to the same extent as the treatment groups. There was no significant change in blood sugar control, capillary blood flow or nerve conduction measures in the supplement groups compared to the placebo group.
The researchers stated that this study suggests that micronutrients supplementation might enhance nerve health in individuals with imbalanced blood sugar metabolism.
Farvid MS, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011 Apr 13.